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Monday, 12 November 2012

Obesity Tx Linked to Liver Failure Risk




People who have undergone bariatric surgery may be at greater risk of acetaminophen-induced acute liver failure, researchers reported.
In a retrospective analysis of 101 liver failure patients, 54 had disease induced by acetaminophen overdose, and of those 16.7% had previous bariatric surgery, according to Edward Holt, MD, of California Pacific Medical Center in San Francisco.
In contrast, among the 47 patients with disease with other causes, there were none who had previously had bariatric surgery, Holt reported at the annual meeting of the American Association for the Study of Liver Diseases (AASLD).
The association appeared to be independent of other factors linked to acetaminophen-induced acute liver failure, including depression, alcohol abuse, the use of combination analgesics, and the intention to commit suicide.
Holt cautioned that the study is retrospective, but suggests a prevalence of bariatric surgery among patients with acetaminophen-induced acute liver failure that is "strikingly higher" than the 0.66% prevalence in the general population.
12/11/2012  :  By Michael Smith  /  Med Page Today.

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